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Old 10-28-2006, 05:37 PM
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mrsD mrsD is offline
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Post more magnesium information..

Magnesium and the heart:
Quote:
1: Heart Fail Rev. 2006 Mar;11(1):35-44.Click here to read Links
The nerve-heart connection in the pro-oxidant response to Mg-deficiency.

* Tejero-Taldo MI,
* Kramer JH,
* Mak IuT,
* Komarov AM,
* Weglicki WB.

Dept. of Biochemistry & Molecular Biology, Div. of Experimental Medicine, The George Washington University Medical Center, Washington, DC 20037, USA. phymit@gwumc.edu

Magnesium is a micronutrient essential for the normal functioning of the cardiovascular system, and Mg deficiency (MgD) is frequently associated in the clinical setting with chronic pathologies such as CHF, diabetes, hypertension, and other pathologies. Animal models of MgD have demonstrated a systemic pro-inflammatory/pro-oxidant state, involving multiple tissues/organs including neuronal, hematopoietic, cardiovascular, and gastrointestinal systems; during later stages of MgD, a cardiomyopathy develops which may result from a cascade of inflammatory events. In rodent models of dietary MgD, a significant rise in circulating levels of proinflammatory neuropeptides such as substance P (SP) and calcitonin gene-related peptide among others, was observed within days (1-7) of initiating the Mg-restricted diet, and implicated a neurogenic trigger for the subsequent inflammatory events; this early "neurogenic inflammation" phase may be mediated in part, by the Mg-gated N: -methyl-D-aspartate (NMDA) receptor/channel complex. Deregulation of the NMDA receptor may trigger the abrupt release of neuronal SP from the sensory-motor C-fibers to promote the subsequent pro-inflammatory changes: elevations in circulating inflammatory cells, inflammatory cytokines, histamine, and PGE(2) levels, as well as formation of nitric oxide, reactive oxygen species, lipid peroxidation products, and depletion of key endogenous antioxidants. Concurrent elevations of tissue CD14, a high affinity receptor for lipopolyssacharide, suggest that intestinal permeability may be compromised leading to endotoxemia. If exposure to these early (1-3 weeks MgD) inflammatory/pro-oxidant events becomes prolonged, this might lead to impaired cardiac function, and when co-existing with other pathologies, may enhance the risk of developing chronic heart failure.

PMID: 16819576 [PubMed - in process]
Magnesium and seizures... including other variables:
http://www.epilepsy.com/epilepsy/provoke_nutrition.html

Magnesium and osteoporosis:
http://www.mdschoice.com/text/abstra...m/magosteo.htm

and while this is relatively new in the lay media...it is not new in the research fields...
Quote:
Magnes Res. 1988 Jul;1(1-2):85-7. Related Articles, Links

Recent data on magnesium and osteoporosis.

Cohen L.

Department of Medicine B, Faculty of Medicine, Technion-Israel Institute of Technology, Lady Davis Carmel Hospital, Haifa, Israel.

Larger and more perfect bone mineral crystals and decreased bone magnesium concentration were found in postmenopausal osteoporosis, senile osteoporosis, alcoholic osteoporosis and osteoporosis associated with thalassaemia. The decreased bone magnesium concentration and the increased retention of magnesium in the magnesium load test suggest magnesium deficiency in post-menoposal osteoporosis, probably caused by magnesium malabsorption.

Publication Types:

* Review


PMID: 3079205 [PubMed - indexed for MEDLINE]
There have been suggestions that chronic low magnesium levels contribute to the formation of bone spurs (the bane of arthritis patients, and spinal patients). I could not at this time find good papers to support this theory, but it remains active on the net.
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