It CAN be used with stem cell replacement, but at this point Mark Freedman at the University of Ottawa is the only researcher I'm familiar with who is still pursuing that route.

The Revimmune process at Johns Hopkins if probably the most prominent and is what most people currently are familiar with. It relies on the fact that certain stem cells are resistant to cyclophosphamide and allows your system to regrow a new (naive) immune system on it's own (hopefully) no longer having the "memory" of MS and requiring all the childhood vaccinations again.

Interestingly, with the idea that someone with MS has obviously shown to have the necessary predispositions, and with the thought being that Copaxone's method of action involves myelin decoys for the aberrant immune cells to harmlessly attack, Revimmune is now followed by Copaxone treatment for a limited time with the hope that the experience will give the naive immune system the training needed to respond correctly this time around ie: never again reverting to MS/autoimmunity.

By some people's definition that might be considered a cure despite the fact that next to nothing is definitively known about the MS disease process. Weird huh?

Bob