Just wanted to share some information I discovered for anyone who is nervous about starting Ty and worrying about PML. (I posted this on another thread on Stumble Inn). I had my first infusion a few days ago. I am still worrying about the risk of being on this drug but what I have come to discover is that for those who cannot tolerate interferons or copaxone a lot of the alternatives have risks too. For example, I just found out that 17 people have gotten PML on the drug Cellcept. That drug is being prescribed off label for MS. It is being used in a drug study at my MS clinic too!! So Ty. isn't looking so bad compared to Cellcept. Rituxan (a chemo drug) that is prescribed for MS off label has had a few cases of PML too (people who had lupus). So the fear mongering about Ty. could easily be directed at these other drugs too. My sense is that because the PML reports came out when Ty. was SO new that it got a lot of press. And the best thing about Ty. is that the side effects are WAY more tolerable than something like Cellcept or Rituxan. In fact, a lot of people don't even have any side effects. I am super sensitive to meds. and I noticed nothing during or after the first infusion except for some mild fatigue.

About cellcept see http://www.medscape.com/viewarticle/576907