Carey:

I've been using Amantadine for about two years, first as an adjunct to Requip, then to Mirapex.

The side effects that I have experienced started in about three months after beginning the Amantadine; they are edema in the feet and lower leg, and "livido reticularis", which is a weird kind of blotchy rash thing, on the forearms and the legs.

For the edema, I've started wearing support stockings, and have simply ignored the rash - it was hidden most of the time, anyway. Now I'm re-thinking that strategy - the latest bit I've read about it says that at least the idiopathic version can cause permanent skin damage. [It also has a connection to Raynaud's phenomenon, if anyone happens to be dealing with both, as I am.]