beyond a shadow of a doubt, that much idiopathic PD is related to either drugs or illness activating Toll Like Receptors which promote an immune response that inflames areas in the brain and begins a cell cascade.

There is a company called Idera, which is working on toll like receptor antagonists, which would silence inflammatory cytokines, such as tumor necrosis factor. The company believes they have drug candidates which will be useful in diabetes and MS.

I think that they don't know it yet, but they may have one of the main therapeutic answers to PD.

JMHO.