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Old 07-22-2008, 05:35 PM
ol'cs ol'cs is offline
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Join Date: Sep 2006
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ol'cs ol'cs is offline
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Join Date: Sep 2006
Posts: 629
15 yr Member
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Drugs like Carbidopa prevent L-Dopa from being deactivated outside the brain, so that there is a higher concentration of L-Dopa in the bloodstream. A higher concentration of l-Dopa in the bloodstream means that there is more L-Dopa available to cross the blood-brain barrier into the brain. Once in the brain, we rely on the same decarboxylase enzymes to produce dopamine from L-Dopa.
Decarboxylation of L-dopa to dopamine outside the brain is a bad thing because dopamine is a cardiostimulant, and we don't want that side effect.
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