Quote:
Originally Posted by aquario
I’ve wondered what, if any, beneficial effects revisiting some of those older plant medicines might have in parkinson’s. Anybody out there have any experience positive or negative? Other well-known tryptamines are psilocybin, ibogaine, and dimethyltriptamine.
Jon
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Noticed the mention of "ibogaine". I continue to be intrigued by the report that the use of Ibogaine increases GDNF. and with the notation above that Ibogaine is a known tryptamine. Madelyn
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http://www.sciencedaily.com/releases...0609170806.htm
"...The research by scientists at theUCSF-affiliatedErnest Gallo Clinic and Research Center builds on their earlier work. In 2005, they reported the first hints that increased levels of this brain protein, known as GDNF, cut down alcohol consumption. The new study established how quickly the effect kicks in, and shows for the first time that the chemical blocks relapse and does not interfere with normal cravings. The research also pinpointed the brain site where GDNF acts to control drinking...
http://neurotalk.psychcentral.com/sh...d.php?p=307040
...The scientists confirmed in a cell model that Ibogaine stimulated GDNF activity. Finally, they showed that a known inhibitor of GDNF blocked Ibogaine's ability to decrease alcohol craving in the rats, suggesting a direct link between Ibogaine's desirable actions and GDNF.
'If we can alter the GDNF pathway, we may well have a new treatment against alcohol and drug addiction without the unwanted side effects of Ibogaine,' Ron said