Daffy, that was a great link. It really explains the behind the scenes of PD, the role of agonists, etc. Leads me to believe more in the importance of antioxidants. Seems to me there is a supplement called NADH but from what I remember it was really expensive. I'd like to ask about a few other things...I ran across an article which studied the neuroprotective effect of CDP choline but can't find it as a supplement-only "choline" which is not the same thing as I understand it. Finally, I stumbled across a site for bio-research that sells human and rat derrived enzymes and antibodies. They listed something like 10ug of GDNF for $295.00. Hmmm..that and a DIY manual and we're on our way, lol.