I was diagnosed in January '08 and began taking both creatine (~10 mg/day) and Dynacirc (Isradipine) (10 mg/day) within about a month and low dose naltrexone (4.5 mg/day) about a month after that. So far my symptoms (left shoulder, arm and hand tremors) haven't progressed, and I am able to control them with resistance training to the point that most of the time I don't notice them. My neurologist is reluctant to attribute the lack of progression to the meds - He says I'm still in the "honeymoon" phase of PD, which, he says can last 4 to 7 years. However, he says it's possible that they actually are working and won't recommend that i stop taking them. I have no plans to do that. I'll continue taking them on the asumption that they are having an effect and see what happens. I do definitely recommend tryiing regular resistance (weight) training as a way to reduce tremor. PS: I recently started taking Inosine and curcumin, also. I guess you could call it a "grab-bag" approach.