I did Rebif for 2 years, went on a vacation, asked the doctor, he said I could stop for that week. When I came home, we both agreed I could go off it, really we both knew I was PPMS and it wasn't helping. But for RRs, it is Russian Roulette. As I told DH, it was reducing my quality of life, would rather feel good while I could still do stuff, no guarantee it would make it better when I was older. But knowing I was really PP made it easy to stop. Sometimes now I wish I could be more pro-active with this, do something. Read about on RRMSer who did HyCy and sailed through it, another MSer got all kinds of complications. It's really hard being sick with all this conflicting info. Do what is best for you and won't be haunted later, no matter what your decision.