Here is what the Physicians Desk Reference says about B6:
Quote:
Doses of vitamin B6, typically in the form of pyridoxine, of up to 200 milligrams daily are generally well tolerated. One report showed severe sensory neuropathy in seven adults after pyridoxine intakes that started at 50 to 100 milligrams/day and were steadily increased to 2 to 6 grams/day over 2 to 40 months. None of the subjects in the report showed sensory neuropathy at doses of pyridoxine of less than 2 grams/day. There is one report of a woman who had been taking 200 milligrams/day of pyridoxine for 2 years without showing sensory neuropathy who developed sensory neuropathy after she increased her pyridoxine dose to 500 milligrams/day. There are rare reports of sensory neuropathy occurring at pyridoxine doses in the range of 100 to 200 milligrams/day. The Food and Nutrition Board of the Institute of Medicine of the U.S. National Academy of Sciences has concluded that reports and studies showing sensory neuropathy at doses of pyridoxine less than 200 milligrams/day are weak and inconsistent, with the weight of evidence indicating that sensory neuropathy is unlikely to occur in adults taking pyridoxine at doses less than 500 milligrams/day.
Other adverse reactions reported with high doses of pyridoxine, include nausea, vomiting, abdominal pain, loss of appetite and breast soreness. Rare cases of pyridoxine-induced photosensitivity have been reported.
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http://www.pdrhealth.com/drug_info/n...vit_0215.shtml
There are certain conditions where even MORE B6 may be needed, such as B6 deficiency or dependency conditions...there are some links here~
http://jccglutenfree.googlepages.com/vitaminb6
I think 50mg P5P would be adequate for most people unless there is a special need (deficiency or dependency conditions). There is some data to support that the risk of adverse affects are minimized by using the P5P form of B6. I actually found that
in print somewhere recently... but now I can't remember where.
Cara