Beer makes mine worse Cold makes it worse too. I haven't taken any drugs that seem to make it worse...not even dramamine for motion sickness. I think this is something that hits everyone a bit different.

Sounds like the benedryl screwed with the wrong brain chemicals and triggered your RLS. I'm sure there is a logical answer, but I would check with a pharmacist on which OTC's could set it off....they know drugs better. But thanks for posting this, as I will ask my doc about it and maybe avoid a problem later on! I know they use Benedryl to help the withdrawl of Paxil (anti depressant) so it does affect the chemicals in the brain somehow that can set off RLS.

They are looking at some Parkinson meds for RSL (I think thats how we got REQUIP). But I'm going to ask my Nuero at our next appt about s o m e t h i n g to help.