I take a combination of Sinemet and Klonopin. I have been on Soma for spasticity which was also supposed to help with RLS, but it has done NOTHING. I am currently tapering off it.

I did try Requip and it did nothing. I know that decongestants make me hyper, Sudafed. But I've never had any problems with Benadryl. Interesting to know that. Thanks.

I hope you get better and find something to help with the RLS. It can be very annoying!