Good luck with the first infusion Polar Express. I go for my second one a week from this Monday. For myself I've decided the risk is worth it at least for a year, maybe two (but I'm not going to tell you I'm completely worry free but I think I will be able to manage it). Hopefully in two years some of the oral medications will be just coming out on the market and we will have a better sense of long term Tysabri use and how many more PML cases there will be. Then I can decide what to do then. Cause the interferons and copaxone are out.