It can take up to seven days for the ivig to show improvement. I know my husband went for the series 5 plasmas and 2 ivigs for about 6 months before anything positive happened - and one day voila - he felt normal again. Unfortunately it only lasted for about a year and a half then it was back to square one - the last 6 months have ben bad - but we're still hopeful that he will have more good days! You must keep positive with this disease - we need to fight for more research!! Hugs to you