"Most cases of Alzheimer's dementia are actually missed B12 deficiency cases, because of the too-low normal range for B12," wrote John V. Dommisse, MD in 1991 in Medical Hypotheses. (3) Dommisse, who practices medicine in Tucson, Arizona, has confirmed (7,8,9) that Alzheimer's disease appears to result from too-low serum vitamin B12, and repletion of the vitamin succeeds despite other risk factors. Repleting B12, according to Dommisse, can reverse 75% of B12 deficiency dementias when the condition is discovered early enough. (10)
Other aspects of the therapy should be noted: The neurological and cerebral manifestations of B12 deficiency require dosages larger, (11) and extending over a longer time, (12) than to those needed to reverse hematologic effects. (13) B12 therapy appears to be perfectly safe; in other words, the risk of overdose is virtually nil. Patients of Dr. H.L. Newbold in New York City injected themselves three times daily with triple-strength doses of B12 (9,000 ug/micrograms/per day) indefinitely. Their serum B12 levels reached 200,000 pg/ml (100 times the normal level found in newborn babies and higher), but none had any significant side effects. (3)