I also have small fiber diagnosis from skin biopsy and still can't find out much else. However my PN neurologist said do not take predisonse till we know what is going on because it will be contraindicated for many disease that may be causes the neuropathy. I know nothing about medicine but just wanted to tell you what I was told. And have they warned you of the terrible effects of using predisone? As I already have bone death you should carefully way the risks and advantages of predisone. Long term use will result in severe bone loss.