I missed my dose of Depakote last night. (Usually 10-ish.) I did call a pharmacy around noon today to ask what to do, as none of the info I had said what to do if you miss a dose. They said since it had been longer than six hours (for extended release), to just take the next dose on schedule. But now I have a migraine. Is it missing the dose, or just other factors? I do seem to get quite a few migraines these last several months.