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Wisest Elder Ever
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Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
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Wisest Elder Ever
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
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...
Now that I have had dinner (after a long day at work  )
I can post the documentation:
Quote:
Definition of Drug-Induced Cognitive Impairment in the Elderly
from Medscape Pharmacotherapy
Drugs Associated With Cognitive Impairment
Taking a thorough drug history is one of the first steps that should be performed when assessing an older patient with changes in cognitive function. This history should include prescription drugs, over-the-counter medications, illicit substances, alcohol use, herbs, vitamins, nutraceuticals, homeopathic products, and naturopathic remedies, including the use of home remedies as well as other forms of complementary or alternative medicine. In the elderly, an increased number of medications may have a greater negative impact on orientation and memory as opposed to concentration and judgment.[28] The more complex a drug regimen, the more difficult it may be to identify the specific drug(s) that may be causing cognitive impairment. It is important to note that in the elderly, drug-induced cognitive impairment may occur even in the presence of nontoxic or therapeutic levels of a drug. Further, there may be intraclass differences in the propensity to induce cognitive impairment.
Numerous drugs have been identified in The Medical Letter on Drugs and Therapeutics as causing a multitude of psychiatric symptoms, including hallucinations, fearfulness, insomnia, paranoia, depression, delusions, bizarre behavior, agitation, anxiety, panic attacks, manic symptoms, hypomania, depersonalization, psychosis, schizophrenic relapse, aggressiveness, nightmares, vivid dreams, excitement, disinhibition, rage, hostility, mutism, hypersexuality, suicidality, crying, hyperactivity, euphoria, dysphoria, lethargy, seizures, Tourette-like syndrome, obsessiveness, fear of imminent death, illusions, emotional lability, sensory distortions, impulsivity, and irritability, which can impact on mental capacity. Further, there are a number of medications that may be linked to causing cognitive impairment by inducing delirium, confusion, disorientation, memory loss, amnesia, stupor, coma, or encephalopathy. Among these drugs are: acyclovir, anticholinergics and atropine, anticonvulsants, tricyclic antidepressants, asparaginase, baclofen, barbiturates, benzodiazepines, beta-blockers, buspirone, caffeine, chlorambucil, chloroquine, clonidine, clozapine, cytarabine, digitalis glycosides, disulfiram, dronabinol, ganciclovir, histamine-2 antagonists, ifosfamide, interleukin-2, ketamine, levodopa, maprotiline, mefloquine, methyldopa, methylphenidate, metrizamide, metronidazole, pergolide, phenylpropanolamine, pilocarpine, propafenone, quinidine, salicylates, seligiline, sulfonamides, trazodone, and trimethoprim-sulfamethoxazole. Often these medications produce more than 1 type of psychiatric symptom.[29]
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Full article:
http://www.medscape.com/viewarticle/408593_5
And this:
Quote:
Psychosomatics 1996; 37:349-355
Copyright © 1996 by Academy of Psychosomatic Medicine
ORIGINAL RESEARCH REPORTS
Famotidine-associated delirium. A series of six cases
G Catalano, MC Catalano and VA Alberts
Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medicine, Tampa, USA.
Famotidine is a histamine H2-receptor antagonist used in inpatient settings for prevention of stress ulcers and is showing increasing popularity because of its low cost. Although all of the currently available H2-receptor antagonists have shown the propensity to cause delirium, only two previously reported cases have been associated with famotidine. The authors report on six cases of famotidine-associated delirium in hospitalized patients who cleared completely upon removal of famotidine. The pharmacokinetics of famotidine are reviewed, with no change in its metabolism in the elderly population seen. The implications of using famotidine in elderly persons are discussed.
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Many doctors do not realize that histamine is a neurotransmitter in the brain.
So H2 antagonists can affect that system. The BBB (blood brain barrier) is different from person to person. The Zonulin channels may let things pass more in one person than another. Zonulin is something hot now in research, and it is also involved in the "leaky gut" scenario, and the gluten folks here are pretty familiar with it. There is even a drug in phase III testing to block zonulin channels and hence prevent peptides for gaining access to where they don't belong.  Zonulin channels are in both the GI tract and the blood brain barrier.
Complicated.... very!
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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