I don't know if there is a direct link but it wouldn't surprise me if the Shingles virus (which is highly opportunistic) pounced on his vulnerability caused by the Lyme. Lyme can cause a huge range of symptoms though so it may be all co-infections from the Lyme. Perhaps they should run the Western Blot cultures after he's done with his antibiotics again to make sure all of the potential co-infections were killed off. That's just my 2 cents.