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Old 11-06-2006, 11:45 AM
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
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mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Post I think it is important,

to clarify the statement that tryptophan is toxic.

From what I have learned about tryptophan is that it is converted to
niacin in ratios of 60mg tryptophan =1mg niacin.

It is an essential amino acid, and will also enhance formation of serotonin.
This later effect IN EXCESS is undesirable in schizophrenia. Some researchers
have found increased positive symptoms when serotonin levels increase in this patient population. (hence SSRIs are not recommended typically either).
http://www.acnp.org/g4/GN401000117/CH115.html

However, when reading ortho's post, it was not clear about that reference to
tryptophan. I would not call it "toxic" myself. This is a rather loaded word, and open to misinterpretation.

Tryptophan has to be transported across the blood brain barrier and is often blocked by 8 other aminos. So typically this feature prevents excessive
movement into the brain.
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