Hi Chelsea, thanks so much for your report. So Happy you are doin so well on LDN..
I'm not surprised that your Friend had to dbl her dose of opiad pain med, if she was taking 25mg of LDN. It is, after all an opiad antagonist at that dose, especially.
At that dose, Naltrexone is working in a completely different way than the low dose works for us.. For us the 3 to 4.5mg works to, only block indorphins temporarily and then causes our endorphin level to increase, correcting our immune system so it does not attack our nerve myelin. (The simple explaination.

)
At 25mg, endorphins are being blocked for too long of a time to recoup. So, that dose would not work for us at all.
Keep checking in..