for some people. It was a Godsend for me back in 1999--- looking at that huge
scalpel the ortho was sharpening on my visits for my inflamed knee.

But I would really not suggest you take it later in the day. It can be very energizing, and cause insomnia. I only take 400mg now first thing when I get up.
If I go below 400mg/day, my arthritis flares.

There is a subset of people who react to SAMe with hypomania. It is not a large
group, but any hyper behavior is something you should pay attention to.

Dr. Walsh from Pfeiffer, has alot to say about who can tolerate methylation and SAMe and who cannot. I can't look it up right now, but those who cannot, should not take it.

From what I know the very high doses, don't need to be taken for a long time.
Most of the studies used only high doses at first, and then cut back to
maintenance ones.

I personally don't use SAMe except when I get up in the early morning, on an empty stomach. I take my 400mg dose then, with my thyroid med. I never went above 600mg/day.

I have severe arthritis, and spondo---the long word--- grade 2. I rarely require pain meds, and can still work, and get around. Just not as much as before, and I do baby myself, and sleep alot when I can.