I understand your worries. I have been on one for several years now. I actually asked to be put back on Effexor because it worked best for me. They changed me to Cymbalta because the DR. thought it would help with my Pain. It did not and the Effexor helps my Mood so much better. But everyone's body reacts different to medication. It's basically trial and error. So don't give up. There are so many different Anti Depressants out there. And stopping any medication cold turkey is not good. I found that out with the cymbalta...it was awful! It also takes 2 to 4 weeks for most to kick in and help. If you have any questions at all please feel free to ask. Be glad to help. Take care Lori T.