I know it seems weird, but I often have an itch on the exact opposite side of my injection. An example: Shot is given into left thigh, later on in the day the right thigh itches in the exact same spot as where my injection was on the left. It's kinda weird and annoying, but I've gotten used to it. Neuro says the signals are getting really confused at figuring out which side it's on.

But incidentally (and back on subject ), are you on copax? Sometimes the med moves away from the injection spot and lumps. I've had that happen too.