That is interesting West.
SAMe is being used in Europe to improve liver functions and treat cirrhosis.
http://cat.inist.fr/?aModele=afficheN&cpsidt=13861436
Quote:
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Dietary methionine is mainly metabolized in the liver where it is converted into S-adenosylmethionine (AdoMet), the main biologic methyl donor. This reaction is catalyzed by methionine adenosyltransferase I/III (MAT I/III), the product of MAT1A gene, which is exclusively expressed in this organ. It was first observed that serum methionine levels were elevated in experimental models of liver damage and in liver cirrhosis in human beings. Results of further studies showed that this pathological alteration was due to reduced MAT1A gene expression and MAT I/III enzyme inactivation associated with liver injury. Synthesis of AdoMet is essential to all cells in the organism, but it is in the liver where most of the methylation reactions take place. The central role played by AdoMet in cellular function, together with the observation that AdoMet administration reduces liver damage caused by different agents and improves survival of alcoholdependent patients with cirrhosis, led us to propose that alterations in methionine metabolism could play a role in the onset of liver disease and not just be a consequence of it. In the present work, we review the recent findings that support this hypothesis and highlight the mechanisms behind the hepatoprotective role of AdoMet.
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More here:
http://www.lef.org/magazine/mag97/june-report972.html
You know, liver functions can go wonky when you have viral infections.
Mono can really throw them off for example. When a viral infection occurs, functions often improve within 6mos.
Concerning Lidoderm... very little is absorbed thru the skin into the circulation, from these patches. I ran Norvasc and Cardizem thru a drug checker and not interactions came up. That is, nothing has entered the data base YET.
Here is a paper on ion channels/lidocaine:
Quote:
The effect of calcium channel antagonist administered by iontophoresis on the pain threshold.
K Taniguchi, A Miyagawa, A Mizutani, N Honda, T Oyama
Department of Anesthesiology, Oita Medical University, Japan.
Three calcium (Ca) channel antagonists were administered to healthy adult volunteers by iontophoresis alone or in combination with lidocaine to study their effects on the pain threshold. Nicardipine, verapamil or diltiazem administered alone elevated the pain threshold to the same degree as lidocaine. When Ca channel antagonists were administered in combination with lidocaine, the pain threshold elevation was not changed, but the duration of the analgesic action was prolonged when compared with lidocaine alone. These results suggest a role of the calcium channel in the pain control mechanism and the possible clinical application of Ca channel antagonists delivered by iontophoresis in pain management.
[Pubmed Record - new window]
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This is the definition of iontophoresis:
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Definition of Iontophoresis
Iontophoresis: A transdermal delivery system in which a substance bearing a charge is propelled through the skin by a low electrical current. This method can be used to drive a drug across the skin barrier, as is done with pilocarpine to stimulate sweating in the sweat chloride test for cystic fibrosis. Iontophoresis can also be used in the reverse direction to draw a molecule such as glucose through the skin.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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