The HiCy stands for high dose cyclophosphamide, meaning that it's being used in high dosage over a few days with the intent to quickly eliminate the immune system rather than being used low dose, long term as a suppressing agent.

Cytoxan/cyclophosphamide has been around for over half a century and has had many uses in that time, including use as an immune suppressant against MS in lower dosages.

Despite the fact that most any sensible person wouldn't want to stand in front of ANY steam roller, the difference between "rebooting" and "long term suppression" is a little like the difference between standing in front of a stopped steam roller as opposed to standing in front of a steam roller that has been slowed down but is still rolling

In both cases a little difference makes for a huge difference in outcome.

At the end of the day it's probably true that the "rebooting" agents themselves are no great miracle, but the discovery of "rebooting" as opposed to "long term suppression" is the exciting difference and eventually, hopefully, a treatment will be discovered which eliminates specifically the factors responsible for MS and it won't be necessary to eliminate the entire immune system.

Bob