I have a lot of PD symtoms and they appear to me to be levodopa responsive. But a movment disorders spec. from U of Miami recently saw me and noticed that I mostly have trouble with my legs and trunk, primarily my thighs and I cannot straighten upright. I have now found that I get some relief from clonazapam very quickly and for some time on just .5 mg. My DBS is not as effective. I dont really get muscular tone relief from it I get relief of dyskinesia when I try to take lots of sinemet to get "on". MY father had been diagnosed with stiff man's and he could only get relief from valium. He died rigid in bed and unable to swallow. It affects your axial or center (trunk) muscles. skeletal and then later the respriatory and swallowing. It is estimated at 1 in 1,000,000 but there are no know genetic connections. I wonder with that few occurrances how can you study it. Any help thanks.