Quote:
Originally Posted by caliTJ
Really? I have run the dosage by my Aunt and she didn't say much...now you have me a bit concerned. I even checked the bottles to make sure I wasn't losing my mind. I will make an apt with an endo today, Thank you. Edited to add that I have always taken my dosage in the evening on an empty stomach....when I was taking it. I went through a period where I didn't take it regularly, and have always believed that is why it stopped working all together. Oh, and you realize I meant 300 AND 400 mcgs, not 3400?
Sorry to highjack your thread Leslie!
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Thyroid hormone is transported via binding proteins.
Here is an example of a common drug that can disrupt this
factor:
http://www3.interscience.wiley.com/j...TRY=1&SRETRY=0
Other drugs also are protein bound, and may displace thyroid hormone.
Poor protein intake can lead to lowered production of these proteins as well.
Another drug that affects thyroid:
http://www.ncbi.nlm.nih.gov/pubmed/346267?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pu bmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pub med_Discovery_RA&linkpos=3&log$=relatedarticles&lo gdbfrom=pubmed
http://endo.endojournals.org/cgi/content/full/146/3/992
This gets pretty complex, but increased metabolism of T4 does occur with some drugs.
Thyroid hormone is suggested to be taken in the morning on an empty stomach with no food for an hour, because the diurnal effects it has. Some people take it at other times, but CONSISTENCY is most important.
Skipping doses interferes with the feedback loop and the hypothalamus. Microgram doses of any drug can be lost in the fiber of the food you eat. Most breakfasts have fiber (cereals).
Digoxin for the heart is also affected this way.
The highest dose of levothyroxine I have seen was .3 mg (300mcg) and that was in one man who was given this before statins were introduced to lower his extremely high and deadly cholesterol.
Also dogs require higher than normal doses compared to humans and I have had several dogs get those .3mg doses as well. I occasionally see .2mg to .250 mg but very rarely, in people. I have never seen a 400mcg dose for a human, in 40 yrs. I suspect you have something going on that requires careful diagnosis by an astute physician.
http://www.medicinenet.com/script/ma...ticlekey=18637
http://thyroid.about.com/gi/dynamic/...teoporosis.htm
I'd like to reiterate that DAILY doses of 300mcg or more are very rare.
Sometimes a doctor will give a larger dose to be taken once a week, or every 5 days in
long term care where oral meds are difficult to administer. (this is to help the nursing staff).
Since T4 (levothyroxine) is long acting, this can be done for difficult patients (hospitalized or in long term care).
Evaluation of adrenal function should be done as well as pituitary.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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