Thanks everyone for your replies. I know that one of the reasons I am being cautious is because of the reactions I have had to the other ms meds. I am also allergic to amoxicillin (ended up in emergency room two days in a row) and sulfa. Everytime a new med is now suggested to me it scares me. I have a three boxes of provigil samples that I have not even opened because I am worried about reactions. They have been sitting here since May. Of course when the doctor gave them to me she said, "now don't have a reaction to this too." After feeling as if I was having heart attacks several times in a fairly short period of time due to IPIR's (copaxone) and tysabri and having my throat close up while on betaseron, I think my caution is reasonable.