Usually anyone who responds well to SAMe is likely to be a high histamine type. High histamine types (histadelics) are also known as undermethylators. Methylation is important because for one thing it is one method the body gets rid of histamine, but DNA methylation is how your body reproduces itself.

If methylation does function properly than your DNA methylation will not function properly either. Everytime your cells reproduce you have a greater risk for some genetic mishap to happen if DNA methylation isn't working properly. This is actually how gene expression gets turned on.

Women, because they have two Y chromosomes, actually have some protection when it comes to DNA methylation. The body somehow will take a correct copy and not use a bad string of DNA. If one y chromosome has some bad DNA it will use the other one. But men because they have two different chromosomes, a y and an x, do not have this proective feature.

SAMe is expensive. Hiistadelics are usually told to supplement methionine. SAMe contains methionine. William Walsh of the Pfeiffer Treatment Center did mention in some notes somewhere on the internet that SAMe is better in the beginning than methionine. But there are other nutrients that you need to take besides SAMe or methionine.