I am no fan of Avonex. BUt here is my advice. Start off with 1/4 dose first week, then half dose the next week and build up to 3/4 dose the following week and full dose the last week.

Be sure to premedicate with the Advil, and then take another two advils 4 to 6 hours later and then a third dose another 4 to 6 hours or so. Then take it the next day if you need to.

Stay very well hydrated on shot day and day after.

Lay low on shot day: dont run around doing errands. Don't exercise on shot day.

The mix it yourself powder form has less severe side effects than the prefilled form of avonex. Biogen doesnt know why, nor are they researching why. It's just reality.

Keep a list of the Lot numbers of your avonex and save the box tear offs with the lot numbers just in case there is another recall of Avonex like in 2004.

If you can, stick with Copaxone instead.

Mayo Clinic rarely prescribes Avonex. They say its for milder forms of MS and they do not treat milder, less aggressive MS. They prescribe C, Rebif, Betaseron instead of Avonex. I do not know their stance on Tysabri though.