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Old 09-12-2008, 07:30 AM
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mrsD mrsD is offline
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Join Date: Aug 2006
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mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Thumbs down Sorbitol and diabetes risk:

Well, I have returned from my vacation. And what happened there to me? Well, I had a very adverse experience with Sorbitol which I discovered is now added to some non-dietetic candies by Hershey's (and it is also being found in other foods more commonly). Sorbitol is a sweetener and also provides a soluble vehicle to other chemicals. In this instance it was in the filling in the new Cherry Cordial Kisses. Because I did not read the label-- I had purchased these before-- I didn't know it.
They were reformulated to have a longer shelf life, and caused me huge inconvenience with unexpected diarrhea.

So now I am looking to see how much Sorbitol is absorbed from the GI tract... and this is not a happy subject.

http://journals.cambridge.org/downlo...fb4dfe7e2a40f0

12% estimate of absorption from the GI tract in this paper.

This paper says 3%
http://www.inchem.org/documents/jecf...no/v05je91.htm

Well, sorbitol is involved in the expression of neuropathy in diabetics:

http://www.inchem.org/documents/jecf...no/v05je91.htm
It is called the polyol pathway.

edit--I forgot the link to this quote:
http://en.wikipedia.org/wiki/Diabetic_neuropathy
Quote:
Furthermore, the high levels of sorbitol are believed to reduce the cellular uptake of another alcohol, myoinsitol, decreasing the activity of the plasma membrane Na+/K+ ATPase pump required for nerve function, further contributing to the neuropathy.

In summary, excessive activation of the Polyol pathway leads to increased levels of sorbitol and reactive oxygen molecules and decreased levels of nitric oxide and glutathione, as well as increased osmotic stresses on the cell membrane. Any one of these elements alone can promote cell damage, but here we have several acting together.

Experimental evidence has yet to confirm that the polyol pathway actually is responsible for microvasculature damage in the retina, kidney and/or neurons of the body. However, physiologists are fairly certain that it plays some role in neuropathy.
Well, the Hershey's company told me they do not have to warn on the label for amounts below 50grams per serving.
I had 9 kisses one day (one serving) and 6 the next a few days later. Both were enough to give me diarrhea. The person I talked to, would not disclose how much sorbitol was in each candy Kiss.

Some of my concern is two fold... Will time show that sorbitol consumed by normal people, may lead to nerve damage?
When non diabetic people consume a laxative like sorbitol regularly, and experience GI upsets, will this be diagnosed as IBS or colitis?
http://www.foodintol.com/food_intolerance/hot_ibs.htm

So at this time, I strongly urge readers here to read their labels. Do not consume food products with sorbitol in them.
One other factor is the rise in drug products that are Liqui-gels. I myself have used Aleve liquigels with great success. But they have sorbitol in them too. Only not as much.
For Aleve..it is listed LAST in the inert ingredients. But as liquigels increase in popularity, this may become a factor too.
NatureMade vitamins just introduced a whole line of new liquigel vitamins. So is it possible to take several of these, and get a significant dose of sorbitol? (I will be calling them later today, to see if sorbitol is in them-- I suspect it is).
I also suspect they buy their liquigels from a specific manufacturer.. Banner.
http://www.pharmcast.com/BuyersGuide...nerComInfo.htm
this is one example.

It is also ironic...most the diabetic dietetic candies marketed to diabetics contain significant
amounts of sorbitol...enough to have a warning on the label!
Please read this:
http://findarticles.com/p/articles/m...26/ai_56027491
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Last edited by mrsD; 09-12-2008 at 01:33 PM.
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dlshaffer (09-12-2008), kalamity_jane (09-12-2008)