Billye~
Mayo has wheelchairs there and also escorts that will take you to your appointments if you need one. You just need to request one when you get there. They won't stay with you the whole day, but after each appointment the area where you are will request an escort and one will come to push you to your next appointment.

If you don't feel you need an escort, always go to subway level to find which building you need to be in before you get into an elevator. The subway level is where everything is marked and you can find your building. There are volunteers standing by the elevators (in blue shirts) to direct people also. Once you follow the signs and find your building, then take that elevator up to the floor you need. There's only one patient/visitor cafeteria and that's on the subway level also.

All hotels are handicapped accessible, have free parking and free shuttle service to Mayo, but the drivers do appreciate a tip.(a buck or two) They drop you off at the front door and pick you up at the front door at certain times. Your hotel will give you a schedule and the Mayo doorman/woman will announce every arriving shuttle. (Shuttle in the far lane going to Best Western Soldiers Field, Holiday Inn, Micortel.....)

I always stay at the Microtel because it's $47.00/night for a single, it's VERY clean, their shuttle starts at 6am, (some don't start till 7am) and the breakfast is great. The Kahler Hotel is connected to Mayo by the subway and is the most expensive hotel, but I hear it is very nice. It is right across the street as someone told you, if you'd want to walk outside you can also.

I live about 2 hours from Rochester and go there quite frequently--lately anyway. If I can answer any questions I'll be more than happy to. Good luck on your trip if I don't talk to you before.
Hugs,
Jan