I have been up most of the night since this struck me. A number of studies have been done. Mostly the idea involves a type of catheter that has to be implanted similar to the diabetic pump. That treatment is based on continuous glucose monitoring and is thought to be the way that diabetics will be managed in the future as opposed to fingersticks during the day.This would be similar to the way that the levodopa would be monitored and administered, through the intestinal wall. Much of the oral dose is broken down prior to its absorption, hence Duodopa. We're not far off and I beg to differ as to the arguments that diet, activity, etc will make this impractile. Diabetics face the same problems and it seems as they have overcome these issues.