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Senior Member (jccglutenfree)
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Join Date: Aug 2006
Location: Wisconsin
Posts: 1,581
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Senior Member (jccglutenfree)
Join Date: Aug 2006
Location: Wisconsin
Posts: 1,581
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Frequency and prognostic value of IgA and IgG endomysial antibodies in recurrent aphthous stomatitis. PMID: 16874419 2006
Quote:
Recurrent aphthous stomatitis is a common disease of the oral mucous membranes. Currently a hypothesis is being discussed that it might be pathogenetically related to coeliac disease. We evaluated the frequency of coeliac disease anti-endomysial (or anti-transglutaminase) antibodies in patients with recurrent aphthous stomatitis. Blood samples from 42 patients were evaluated and 2/42 (4.7%) were IgA- and IgG-endomysial antibody-positive. None of the 42 persons in the control group had antibodies, which was not statistically different from the patient group. The two antibody-positive patients had episodes of mild gastrointestinal symptoms only, but histopathology of duodenal mucous membranes confirmed coeliac disease. All symptoms related to aphthous stomatitis responded well to a gluten-free diet. We conclude that every patient with recurrent aphthous stomatitis should be asked about a history of gastrointestinal complaints and screened for markers of coeliac disease, since recurrent aphthous stomatitis may in some cases respond to a gluten-free diet.
PMID: 16874419
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