hjmom,
You know, I've been having water retention all the time and it seems to be since I've been on the meds. I never even thought of the possible connection until you mentioned it. My ankles don't necessarily swell, for me it's more of a body thing, where my arms, legs and torso seem fatter (lol) but they're not and this will increase and decrease daily. The only day I thin down is the actual day I begin my monthy cycle. So one day out of the month I fit perfectly into my clothes. It's kind of ridiculous. I've been attributing this to the actual cycle itself. Hmmm... The possibility of the Avonex causing it is something to consider. Thanks!