I haven't tried many meds for my fatigue (except initally A/D's, and LDN), but my MS Specialist is of the impression that we should simply sleep when we need to, i.e. it's our body's way of telling us to slow down, if only for a few hours.

Besides the fact that I am a terribly unreliable employee at the best of times now, my MS Specialist thinks that we should "go with the flow" as much as possible. Stressing or taxing our body beyond it's current capability (at any given time) is a no-no as far as she's concerned.

Oddly, the one thing I found that did make a difference in this regard, was going off A/D's. I wasn't able to do that until I got on LDN, but between the two changes, my fatigue let up considerably. (Ironically, I was put on A/D's originally to hopefully HELP the fatigue. )

If this is a sudden change for you, I wonder if you may be relapsing. Have you noticed any other changes at the same time; weaker legs, numbness/tingling, cognitive problems, etc.? Personally I first go get checked for any unnoticed infection that might be going on (UTI, etc.) because when I have one my symptoms (and fatigue levels) always act up.

Cherie