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In Remembrance
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Join Date: Aug 2006
Posts: 3,772
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In Remembrance
Join Date: Aug 2006
Posts: 3,772
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Trifolium is a fancy name for red clover
1: Neurosci Res. 2008 Oct;62(2):123-30. Epub 2008 Jul 16.
Protective effect of isoflavones from Trifolium pratense on dopaminergic neurons.
Chen HQ, Wang XJ, Jin ZY, Xu XM, Zhao JW, Xie ZJ.
State Key Laboratory of Food Science and Technology, Jiangnan University, 1800
Lihu Road, Wuxi, Jiangsu 214122, PR China; School of Food Science and Technology,
Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, PR China.
In the present study, protective effect of five isoflavones (formononetin,
daidzein, pratensein, calycosin and irilone) from Trifolium pratense on
lipopolysaccharide-induced dopaminergic neurodegeneration was studied for the
first time. The results showed that all five isoflavones attenuated LPS-induced
decrease in dopamine uptake and the number of dopaminergic neurons in a
dose-dependent manner in rat mesencephalic neuron-glia cultures. Moreover, they
also significantly inhibited LPS-induced activation of microglia and production
of tumor necrosis factor-alpha, nitric oxide and superoxide in mesencephalic
neuron-glia cultures and microglia-enriched cultures. In addition, the rank order
of protective potency of five isoflavones was:
pratensein>daidzein>calycosin>formononetin>irilone . This study suggested that all
five isoflavones protected dopaminergic neurons against LPS-induced injury
through inhibition of microglia activation and proinflammatory factors
generation.
PMID: 18675857 [PubMed - in process]
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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