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It turns out that pro-inflammatory cytokines cause tryptophan to degrade in the blood. This occurs because these pro-inflammatory cytokines activate specific enzymes that deplete tryptophan in the bloodstream. The result of diminished blood levels of tryptophan is serotonin deficiency in the brain (and the onset of depression).
Pro-inflammatory cytokines are specialized biochemicals secreted by immune cells that are only supposed to be activated in response to acute infection or trauma. As people age, they often chronically overproduce pro-inflammatory cytokines, which subsequently cause inflammatory-related diseases such as arthritis, cancer, dementia and depression, and atherosclerosis.
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It turns out that interferon drugs cause tryptophan-degrading enzymes to surge, thus depleting tryptophan in the blood and making less tryptophan available for conversion to serotonin in the brain.
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From LifeExtension Mag April 2008
http://www.lef.org/magazine/mag2008/...Cruel-Hoax.htm
Guess what is elevated in MS and does much of the damage???
Yep!! Pro-inflammatory cytokines!!!!
jackD