25 mgs. of Topamax is a tiny dosage. Even 50 mgs. is small. If 25 or 50 mgs. does the trick or helps a lot...you would be in good shape. It might very well be that some Topamax and a little of a second medication will make a nice difference for you. Throw in a good diet and some supplements it could be even better. In terms of the Topamax side effects, it's hard to say. It has been my experience that if you increase the dosage, to go slowly. AND to try not to take any high dosages of this medication since the side effects are dosage related. I do think it could take a few days to fully enter the system. Drink lots of water because I do believe this helps a little as well.