some people have a genetic error in thiamine metabolism. This leads to
what is called a dependency state (not a deficiency). This means that
normal levels do NOT work for them, and they need more.
So normal serum levels, mean nothing for those people.
A biochemist from OBT found this information, that it is linked to familial
alcoholism genes. These may not express in alcoholism for that patient, but
they do interfere with thiamine metabolism. So extra thiamine works for these
folks. Some drugs deplete thiamine also... diuretics like furosemide, and others, antibiotics, and sulfa drugs.
Because thiamine is so cheap and easy to use, it is worth a try. It works extremely well for me, in the 200mg/day range. (My paternal grandfather was an alcoholic-- that is the closest family member with that problem to me).
here is a good reference:
http://www.springboard4health.com/notebook/v_b1.html
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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