Personally, I have found the Baclofen has been the best drug for control of my RSD induced CNS spasms. I take 10 mg., 4 times a day, and understand that some folks with severe dystonia take significantly higher dosages than that. The only downside is that it plays havoc with my short term memory, to the point that I couldn't use it when I was practicing law, but now that I'm "retired" it's no longer an issue.