Minocycline and tetracycline are hard on the body. Over time
they cause significant dysbiosis of the GI tract which may even lead to C.difficile infections/colitis.
They also deplete a boatload of nutrients..a very long list.

The Penicillins are easier to tolerate. Penicillin VK has a narrower spectrum of action (but it does hit Strep) and the fewest side effects over time. Amoxicillin may cause GI problems, Candida and colitis with time. Same with cephalexin.

Luckily for PANDAs patients the pen VK is often enough. But when you don't know exactly what you need to kill off, well, choice of drug then becomes more difficult.

Minocycline and tetracycline and doxycycline are all bacteriostatic--they do not kill only prevent spread.

The penicillins do kill bacteria.

The tetracycline family has been used in the treatment of rheumatic disorders for their anti-inflammatory actions.

If anyone here decides to go the minocycline route, then PM me and I'll get you the list of nutrients you need to attend to.

Also plan on using a good probiotic and/or a good yogurt daily, with any long term antibiotic. Stay away from the fluroquinolones..they are CNS toxic.