I just joined tonight. Thank you all for the posts .I thought I was alone with the pain getting so much worse at night. It keeps me up late. The ONLY way I can sleep at all is to take the Tramadol.and usually I also need a Vicodin. My legs are very bad. I never take the same amount of Tramadol in a day. Right now, I am only taking it at bedtime. But in the beginning I took it four times a day. Then I cut back to twice a day.....at 10:00 AM and at bedtime. But, I have decided I really only need it to sleep. I have been on it for a couple years. If I don't take it I do not sleep and lay there until 4:00 AM exhausted..and that doesn't help me much the next day. BTW, I am post liver transplant and nerves can be severed in the process of opening you up. Again, thank you all for your help. Joanne C.