Ron's been using it for years and you just can't stop the fellow. The only caveat I can think of is if you have h pylori grt rid of it first or take a hardened tablet that will get past the stomach before disinterating. Curcumin kills HP better than any antibiotic. Also, maximum bio-availability comes from taking it with a little oil of some sort.

1: Int J Biochem Cell Biol. 2008 Jul 9. [Epub ahead of print]

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against
neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and
neoplastic diseases.

Aggarwal BB, Harikumar KB.

Cytokine Research Laboratory, Department of Experimental Therapeutics, The
University of Texas M. D. Anderson Cancer Center, Houston, TX, United States.

Although safe in most cases, ancient treatments are ignored because neither their
active component nor their molecular targets are well defined. This is not the
case, however, with curcumin, a yellow-pigment substance and component of
turmeric (Curcuma longa), which was identified more than a century ago. For
centuries it has been known that turmeric exhibits anti-inflammatory activity,
but extensive research performed within the past two decades has shown that this
activity of turmeric is due to curcumin (diferuloylmethane). This agent has been
shown to regulate numerous transcription factors, cytokines, protein kinases,
adhesion molecules, redox status and enzymes that have been linked to
inflammation. The process of inflammation has been shown to play a major role in
most chronic illnesses, including neurodegenerative, cardiovascular, pulmonary,
metabolic, autoimmune and neoplastic diseases. In the current review, we provide
evidence for the potential role of curcumin in the prevention and treatment of
various proinflammatory chronic diseases. These features, combined with the
pharmacological safety and negligible cost, render curcumin an attractive agent
to explore further.