when i started mestinon i started with 1/2 tab 30mg and then after 4 weeks i started 1 tab every 4 hours and now i take 60 mg every 3 hours for a total of 5 tabs a day but if i dont eat i get the overdose effect now he wants to increase it another 60 mg not sure if i really want that i hate it when i get the twitching and i also take cyclosporine and prednisone wish i can stop everything maybe one day