When I was in the hospital (mental hospital) this past March I was told that ANY narcotic, whether it is prescribed or not, would in essence zero out the effect of my psych meds and it would be like I had not taken them at all. Now I have noticed with some of the operations I have had, coming home I had to go right back into the mental hospital to get my meds straightened out, but I was on a morphine pump, so that I can understand. However, can taking the hydrocodone off and on for pain (mainly migraines) totally nix the psych meds?? Does anyone have any experience taking this sort of mix?