Another SPMS person here and I just turned 65 this past Friday. Dx in 1990 with RRMS but think I've had "IT" since 1976 when I developed optic neuritis after my third child was born. Remission until '90. Been taking LDN for over three years after bad reactions to the injectables. The neuro says I seem to be stable, but deal with LOTS of pain. Meds: LDN, Zoloft, Oxybutynin, Omeprazole, Aleve, Atenolol for mitral valve prolapse, Warfarin for atril fibrillation, iron, Diazapam for spasms, generic Tegretol when nerve pain is extra bad and dexamethasone pills for any type of flare since a needle will no longer stay in my veins. Hope that answers your questions. I do use a powerchair or scooter all the time but still live alone with some help.