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In Remembrance
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Join Date: Aug 2006
Posts: 3,772
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In Remembrance
Join Date: Aug 2006
Posts: 3,772
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1: J Neurosci Res. 2008 Feb 1;86(2):326-38.
Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the
adult rodent brain and induces recovery in an animal model of Parkinson's
disease.
Bertilsson G, Patrone C, Zachrisson O, Andersson A, Dannaeus K, Heidrich J,
Kortesmaa J, Mercer A, Nielsen E, Rönnholm H, Wikström L.
NeuroNova AB, Stockholm, Sweden.
We investigated the effects of exendin-4 on neural stem/progenitor cells in the
subventricular zone of the adult rodent brain and its functional effects in an
animal model of Parkinson's disease. Our results showed expression of GLP-1
receptor mRNA or protein in the subventricular zone and cultured neural
stem/progenitor cells isolated from this region. In vitro, exendin-4 increased
the number of neural stem/progenitor cells, and the number of cells expressing
the neuronal markers microtubule-associated protein 2, beta-III-tubulin, and
neuron-specific enolase. When exendin-4 was given intraperitoneally to naïve
rodents together with bromodeoxyuridine, a marker for DNA synthesis, both the
number of bromodeoxyuridine-positive cells and the number of neuronal precursor
cells expressing doublecortin were increased. Exendin-4 was tested in the
6-hydroxydopamine model of Parkinson's disease to investigate its possible
functional effects in an animal model with neuronal loss. After unilateral lesion
and a 5-week stabilization period, the rats were treated for 3 weeks with
exendin-4. We found a reduction of amphetamine-induced rotations in animals
receiving exendin-4 that persisted for several weeks after drug administration
had been terminated. Histological analysis showed that exendin-4 significantly
increased the number of both tyrosine hydroxylase- and vesicular monoamine
transporter 2-positive neurons in the substantia nigra. In conclusion, our
results show that exendin-4 is able to promote adult neurogenesis in vitro and in
vivo, normalize dopamine imbalance, and increase the number of cells positive for
markers of dopaminergic neurons in the substantia nigra in a model of Parkinson's
disease. (c) 2007 Wiley-Liss, Inc.
PMID: 17803225 [PubMed - indexed for MEDLINE]
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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